Human collagen has less immunoreactivity, is used for superficial wrinkles and lasts three to seven months. Nodular reactions have been reported, which have resolved with 0.1% tracolimus Alvera Tone Review. There is also the porcine collagen.
Hyaluronic acid: this acid has been used for nasolabial, mesolabial, lip volume and glabellar lines with high percentages of patient satisfaction.
It has been seen that in photoaged skins the fibroblasts are collapsed compared with photoprotected skins, and that this is due to the loss in the mechanical tension of the fibroblast Alvera Tone Review, which can be restored with the injection of filling materials.